Antioxidants received from plant sources are found to be one of the best remedies for a number of human diseases. Guava with high amount of dietary fiber is recommended as natural and secured source of antioxidants. In this study, antioxidant capacity in guava fruits is determined by the assessment of total phenol content and DPPH scavenging activity. Results obtained emphasize on the usage guava fruits to eradicate destructive free radicals from the human body. Daily intake of guava fruits can help fighting noxious diseases like cancer and arthritis.